Increased Adhesion and Aggregation of Platelets Lacking Cyclic Guanosine 3′,5′-Monophosphate Kinase I
نویسندگان
چکیده
منابع مشابه
Increased Adhesion and Aggregation of Platelets Lacking Cyclic Guanosine 3 9 , 5 9 - Monophosphate Kinase I
From the * Institut für Chirurgische Forschung der Ludwig-Maximilians-Universität München, 81377 München, Germany; the ‡ Institut für Pharmakologie und Toxikologie der Technische Universität München, 80802 München, Germany; the § Institut für Prophylaxe und Epidemiologie der Kreislaufkrankheiten, Klinikum Innenstadt, Universität München, 80336 München, Germany; and the i Department of Experimen...
متن کاملIncreased Adhesion and Aggregation of Platelets Lacking Cyclic Guanosine 3′,5′-Monophosphate Kinase I
Atherosclerotic vascular lesions are considered to be a major cause of ischemic diseases, including myocardial infarction and stroke. Platelet adhesion and aggregation during ischemia-reperfusion are thought to be the initial steps leading to remodeling and reocclusion of the postischemic vasculature. Nitric oxide (NO) inhibits platelet aggregation and smooth muscle proliferation. A major downs...
متن کاملIncreased Adhesion and Aggregation of Platelets Lacking Cyclic Guanosine 3 9 , 5 9 - Monophosphate Kinase
From the * Institut für Chirurgische Forschung der Ludwig-Maximilians-Universität München, 81377 München, Germany; the ‡ Institut für Pharmakologie und Toxikologie der Technische Universität München, 80802 München, Germany; the § Institut für Prophylaxe und Epidemiologie der Kreislaufkrankheiten, Klinikum Innenstadt, Universität München, 80336 München, Germany; and the i Department of Experimen...
متن کاملCyclic guanosine monophosphate-dependent protein kinase I promotes adhesion of primary vascular smooth muscle cells.
The cyclic guanosine monophosphate (cGMP)/cGMP-dependent protein kinase type I (cGKI) pathway regulates many cellular functions. The current study shows that 8-Br-cGMP stimulates the number of attached primary but not that of subcultured murine vascular smooth muscle cells (VSMCs). These effects of 8-Br-cGMP require the presence of cGKI. In agreement with previous studies, cGKI inhibited the nu...
متن کاملCyclic Guanosine Monophosphate
Since we have previously shown a direct inhibitory effect of platelet-activating factor (PAF) on Cl reabsorption in the medullary thick ascending limb of Henle's loop (TAL), the aim of this study was to extend this effect to the whole TAL and to further investigate the signaling pathway involved. In microperfused cortical TALs, PAF significantly decreased Cl reabsorption by 50.3±6.5%. On the on...
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ژورنال
عنوان ژورنال: Journal of Experimental Medicine
سال: 1999
ISSN: 0022-1007,1540-9538
DOI: 10.1084/jem.189.8.1255